ANTI-MICROBIAL ACTIVITY OF SOME Pt(II) COMPLEXES BEARING 8-OXYQUINOLINE (8-OQ) AND EUGENOL DERIVATIVE AND 3D-STRUCTURE OF COMPLEX [PtCl(8-OQ)(EUGENOL)]

Authors

  • Nguyen Hoang Ninh Faculty of Chemistry, Hanoi National University of Education, Hanoi city, Vietnam
  • Dang Xuan Nhat Sang Faculty of Chemistry, Hanoi National University of Education, Hanoi city, Vietnam
  • Duong Manh Hieu Faculty of Chemistry, Hanoi National University of Education, Hanoi city, Vietnam
  • Nguyen Thi Thanh Chi Faculty of Chemistry, Hanoi National University of Education, Hanoi city, Vietnam

DOI:

https://doi.org/10.18173/2354-1059.2024-0026

Keywords:

arylolefin, anti-microbial activities, DFT calculation, NOESY spectrum, Pt(II) complex

Abstract

Four complexes including [PtCl(8-OQ)](arylolefin)] (arylolefin: Eug, M1; Aceug, M2, Eteug, M3, Preug, M4) were obtained by the reaction between 8-hydroxyquinoline and K[PtCl3(arylolefin)]  in high yields. The 3D structure of M1 has been determined for the first time by DFT calculation combined with the experimental NOESY spectrum. The result showed that M1 exists as distorted square-planar coordination with angles of O-Pt-Cl and N-Pt-O of 176.4o and 81.0o respectively. In which 8-OQ coordinates with Pt(II) through both the N and O atoms, Eug bonds with Pt(II) via the C=Cally and in trans position to the N atom of 8-OQ. The investigation of the biological activities of the synthesized complexes showed that they display weak anti-bacterial and antifungal activities.

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Published

27-06-2024