CHARACTERIZATION OF A CHITOSAN/POLYANILINE FILM LOADED WITH LOVASTATIN
DOI:
https://doi.org/10.18173/2354-1059.2025-0056Keywords:
chitosan/PANi/lovastatin biocomposites, chitosan/lovastatin biocomposites, lovastatin release, polyanilineAbstract
This research aims to address these challenges by dispersing the drug within both a single biopolymer matrix (chitosan) and a dual biopolymer matrix (chitosan/polyaniline). The results indicated that, among the single-matrix chitosan/lovastatin (CsL) samples, the CsL10 CsL10 exhibits the most favorable drug-release behavior over 30 h, achieving a cumulative release of 96% in simulated intestinal fluid (pH 7.4) while providing effective drug protection of 10.5% in simulated gastric fluid (pH 2.0). These findings suggest a promising platform for further development. Building upon this direction, the study was extended to incorporate polyaniline to enable live-function monitoring and tissue stimulation. The results showed that the chitosan/polyaniline/lovastatin (CsPL) samples met the initial expectations, with the CsPL7 sample exhibiting drug release rates of 92.23% and 18.58% in the simulated intestinal and gastric environments, respectively. Analytical techniques, including FT-IR, FESEM, DSC, and UV-Vis, were employed to gain a deeper understanding of the interactions between the polymer components and the drug substance.
References
[1] Henwood JM & Heel RC, (1988). Lov: a preliminary review of its pharmacodynamic properties and therapeutic use in hyperlipidaemia. Drugs 36(4), 429-454.
[2] Chandrasekaran M, Kim KD & Chun SC, (2020). Antibacterial activity of chitosan nanoparticles: A review. Processes, 8(9), 1173.
[3] Alberts AW, (1990). Lov and simvastatin-inhibitors of HMG CoA reductase and cholesterol biosynthesis. Cardiology, 77(Suppl 4), 14-21. Doi: 10.1159/000174688
[4] Nguyen NL, Vu QM, La CG, Nguyen TC, Hoang TD, Tran TTD, Thai H & Vu QT, (2024). Assessment of the hemostatic ability of biomaterial based on chitosan and Eclipta prostrata L. extract. Biomedical Materials, 19(3), 035026.
[5] Dam XT, Duong TM, Mai DH, Thai H, Vu VA, Vu QT, Ngo TCQ, Nguyen TA & Nguyen TC, (2024). Preparation of the novel bio‐nanocomposites based on chitosan, Piper betle leaf extract, and MgO nanoparticles for chili preservation. Polymer Engineering & Science, 64(6), 2795-2811.
[6] Ha MH, Vu QM, Vu TTT, Dao TPT, Pham TD, Nguyen TBV, Duong KL, Nguyen NL, Doan TYO, Nguyen TC, Thai H & Vu QT, (2022). Evaluation of the effect of the chitosan/carrageenan ratio on Lov release from chitosan/carrageenan based biomaterials. Vietnam Journal of Chemistry, 60(S1), 72-78.
[7] Karimi M, Ghasemi A, Zangabad PS, Rahighi R, Basri SMM, Mirshekari H & Hamblin, (2016). pH-Responsive polymers: Synthesis, properties, and applications in drug delivery. Advanced Drug Delivery Reviews, 107, 1-26.
[8] Zhang Y, Zhou M, Dou C, Ma G, Wang Y, Feng N, Wang W & Fang L, (2019). Synthesis and biocompatibility assessment of polyaniline nanomaterials. Journal of Bioactive and Compatible Polymers, 34(1), 16-24.
[9] Pramanik N, Dutta K, Basu RK & Kundu PP, (2016). Aromatic π-conjugated curcumin on surface-modified polyaniline/polyhydroxy alkanoate-based 3D porous scaffolds for tissue engineering applications. ACS Biomaterials Science & Engineering, 2(12), 2365-2377.
[10] Fan Q, Sirkar KK & Michniak B, (2008). Iontophoretic transdermal drug delivery system using a conducting polymeric membrane. Journal of Membrane Science, 321(2), 240-249.
[11] Zhang L, Zhang Z, Kilmartin PA & Travas-Sejdic J, (2011). Hollow polyaniline and indomethacin composite microspheres for controlled indomethacin release. Macromolecular Chemistry and Physics, 212, 2674-2684.
[12] Shokry H, Vanamo U, Wiltschka O, Niinimäki J, Lerche M, Levon K, Linden M & Sahlgren C, (2015). Mesoporous silica particle-PLA–PANI hybrid scaffolds for cell-directed intracellular drug delivery and tissue vascularization. Nanoscale, 7, 14434-14443.
[13] Yang YF, Meng FY, Li XH, Wu NN, Deng YH, Wei LY & Zeng XP, (2019). Magnetic graphene oxide-Fe3O4-PANI nanoparticle adsorbed platinum drugs as drug delivery systems for cancer therapy. Journal of Nanoscience and Nanotechnology, 19(12), 7517-7525.
[14] Minisy IM, Salahuddin NA & Ayad MM, (2021). In vitro release study of ketoprofen loaded chitosan/polyaniline nanofibers. Polymer Bulletin, 78, 5609-5622.
[15] Ghorbani F & et al., (2022). A smart magnetic chitosan/agarose/halloysite nanotube hydrogel for sustained release of doxorubicin. International Journal of Biological Macromolecules, 219, 216-227.
[16] Webber V, Carvalho SM, Ogliari PJ, Hayashi L & Barreto PLM, (2012). Optimization of the extraction of carrageenan from Kappaphycus alvarezii using response surface methodology. Food Science and Technology, 32(4), 812-818.
[17] Sirotkin N & Khlyustova A, (2023). Plasma synthesis and characterization of PANI + WO₃ nanocomposites and their supercapacitor applications. Journal of Composites Science, 7(4), 174.
[18] Drabczyk A, Kudłacik-Kramarczyk S, Głąb M, Kędzierska M, Jaromin A, Mierzwiński D & Tyliszczak B, (2020). Physicochemical Investigations of Chitosan-Based Hydrogels Containing Aloe Vera Designed for Biomedical Use. Materials, 13, 3073.
[19] Jamil B, Habib H, Abbasi S, Nasir H, Rahman A, Rehman A & Imran M, (2016). Cefazolin-loaded chitosan nanoparticles to cure multidrug-resistant Gram-negative pathogens. Carbohydrate Polymers, 136, 682-691.
[20] Bhadra J & Sarkar D, (2019). Effect of dopant type on the properties of polyaniline-based nanocomposites. Polymer Bulletin, 76(8), 4275-4289.
[21] Luo Y, Liu J, Zeng J & Pan H, (2024). Global burden of cardiovascular diseases attributed to low physical activity: An analysis of 204 countries and territories between 1990 and 2019. American Journal of Preventive Cardiology, 17, 100633.
[22] Loc TT, Thai H, Nguyen TC & Le DG, (2018). The effects of the compatibilizers on the lovastatin release form the alginat/chitosan/Lov composite. Vietnam Journal of Chemistry, 56(3), 389-395 (in Vietnamese).
